吕 钊

个人简介：

吕钊，男，汉族，湖南新宁人，中共党员，博士，特聘教授，硕士研究生导师，国家大宗淡水鱼产业技术体系常德综合试验站站长，湖南省优青、山东省优秀博士学位论文获得者，研究方向为水产动物免疫与育种。兼任全国执业兽医资格考试（水生动物类）命题专家、湖南省水产学会理事、湖南省生理科学会理事和长沙市水产学会理事。

联系方式：

E-mail：lvzhao_0320@hunau.edu.cn

办公室：求索楼204

教育经历：

2010.09-2014.07，南京农业大学动物科学技术学院，水产养殖学本科

2014.09-2019.07，中国科学院海洋研究所，理学博士；导师：宋林生研究员

工作经历：

2019.07-2021.12，湖南农业大学水产养殖系，博士后；合作导师：肖调义教授

2021.07-至   今，湖南农业大学神农学者Ⅲ层次人才、特聘教授

主讲课程：

鱼类学（本科）、水产动物育种学（本科）、生物信息与数据分析（研究生）

主要研究方向：

1.水产动物免疫遗传学

2.水产动物抗病育种

代表性科研课题:

1.现代农业产业技术体系专项，国家大宗淡水鱼产业技术体系常德综合试验站，50万元，2024.01-至今，主持

2.国家自然科学基金青年项目，IL-10基因启动子区GAGTT插入/缺失变异影响草鱼出血病抗性的作用机理，30万元，2024.01-2026.12，主持

3.湖南省优秀青年项目，草鱼IL-10基因变异的炎症调控作用特点与育种价值评估，20万元，2025.01-2027.12，主持

4.国家自然科学基金联合基金重点项目，草鱼抗GCRV主效功能分子筛选及其遗传机制解析，263万元，2021.01-2024.12，主要完成人

代表性论文：

1.Ding C, Xiao T*, Deng Y, Yang H, Xu B, Li J, Lv Z*. The Teleost CXCL13–CXCR5 Axis Induces Inflammatory Cytokine Expression through the Akt–NF-κB, p38–AP-1, and p38–NF-κB Pathways. The Journal of Immunology, 2024, 212(2):19. (*通讯作者)

2.Yang H, Fu J, Zhang M, Cao X, Xiao Y, Wang H, Xiao T, Lv Z*. A specific GAGTT insertion/deletion variation in the IL-10 gene promoter alters the disease resistance of grass carp. Aquaculture, 2025, 595(Part1), 741505. (*通讯作者)

3.Yang H, Qin B, Fu J, Zhang M, Wang H, Xiao T, Lv Z*. Molecular characteristics and functional differentiation of two IL-10 genes in barbel chub Squaliobarbus curriculus. Fish & Shellfish Immunology, 2025, 165:110514. (*通讯作者)

4.Yang H, Xiao T*, Deng Y, Ding C, Zhang M, Li J, Lv Z*. JunD functions as a transcription factor of IL-10 to regulate bacterial infectious inflammation in grass carp (Ctenopharyngodon idella). International Journal of Biological Macromolecules, 2023, 258 (P2), 129045. (*通讯作者)

5.Xiong X, Yang H, Ding C, Qin B, Deng Y, Xiong L, Liu X, Li Y, Xiao T*, Lv Z*. Functional and expression analysis reveals the involvement of integrin αvβ3 in antiviral immunity of grass carp (Ctenopharyngodon idella). Fish & Shellfish Immunology, 2022, 129:52-63.(*通讯作者)

6.Deng Y, Ding C, Yang H, Zhang M, Xiao Y, Wang H, Li J, Xiao T*, Lv Z*. First in vitro and in vivo evaluation of recombinant IL-1β protein as a potential immunomodulator against viral infection in fish. International Journal of Biological Macromolecules, 2023, 255, 128129.(*通讯作者)

7.Yang H, Qin B, Fu J, Zhang M, Wang H, Xiao T*, Lv Z*. Nuclear scaffold attachment factor A functions as a potential viral recognition receptor involved in the antiviral immunity of grass carp (Ctenopharyngodon idella). International Journal of Biological Macromolecules, 2025, 308 (Pt 1):142337. (*通讯作者)

8.Ding C, Wang Q, Yuan S, Ye J, Yang Z, Zhou Y*, Lv Z*. Astragalus polysaccharides enhance the immune response and resistance of grass carp against grass carp reovirus. International Journal of Biological Macromolecules, 2026, 352, 151046.(*通讯作者)

9.Huang J#, Lv Z#, Li B, Ying Y, Yang L, Xiao T*, Xiong S*. Characterization of multi-copy C3 genes and association analysis of C3.1 polymorphism with GCRV resistance traits in Ctenopharyngodon idella. Aquaculture, 2024, 583, 740567.(#共同第一作者)

10.Wei Y, Li B, Long Z, Du Z, Lv Z*, Xiao T*. Analysis of metabolic characteristics of highly resistant grass carp bred on the basis of constitutive expression level of innate immune molecules. Fish & Shellfish Immunology, 2025, 166,110604.(*通讯作者)

11.Lv Z*, Zhang M, Xu Y,i Qin B, Yang H, Wei R, Xiao T. Structural and Functional Characteristics of TLR19 in Barbel Chub Compared to TLR19 in Grass Carp. International Journal of Molecular Sciences, 2025, 26 (7):3103.(*通讯作者)

12.Xiao Y#, Lv Z#, Wei Y, Zhang M, Yang H, Huang C, Xiao T*, Li Y*. Molecular Characterization and Antiviral Function Against GCRV of Complement Factor D in Barbel Chub (Squaliobarbus curriculus). Fishes, 2025, 10 (8):370.(#共同第一作者)

13.Liu Y, Lv Z*, Xiao T, Zhang X, Ding C, Qin B, Xu B, Liu Q*. Functional and Expressional Analyses Reveal the Distinct Role of Complement Factor I in Regulating Complement System Activation during GCRV Infection in Ctenopharyngodon idella. International Journal of Molecular Sciences, 2022, 23 (19):11369.(*通讯作者)

14.黄嘉杨, 李彬, 王红权, 余建波, 龙哲, 阳鸿, 刘巧林, 许宝红, 李耀国, 胡旭东, 赵祥, 李成, 彭治桃, 黄超, 吕钊*, 肖调义*. 基于先天性免疫分子表达水平的草鱼亲本选择及其子代抗病性能评估. 水产学报, 2025.(*通讯作者)

15.阳鸿, 邓亚东, 丁春华, 许宝红, 吕钊*, 肖调义*. GCRV感染存活草鱼的血清蛋白表达特性. 水生生物学报, 2024, 48 (02): 304-314.(*通讯作者)

16.Qin B, Xiao T, Ding C, Deng Y, Lv Z*, Su J*. Genome-Wide Identification and Expression Analysis of Potential Antiviral Tripartite Motif Proteins (TRIMs) in Grass Carp (Ctenopharyngodon idella). Biology, 2021, 10(12):1252. (*通讯作者)

17.Ding C, Xiao T, Qin B, Xu B, Lv Z*, Wang H*. Functional Identification of Complement Factor D and Analysis of Its Expression during GCRV Infection in Grass Carp (Ctenopharyngodon idella). International Journal of Molecular Sciences, 2021, 22(21):12011. (*通讯作者)

18.Lv Z, Hu Y, Tan J, Wang X, Liu X, Zeng C*. Comparative Transcriptome Analysis Reveals the Molecular Immunopathogenesis of Chinese Soft-Shelled Turtle (Trionyx sinensis) Infected with Aeromonas hydrophila. Biology, 2021, 10(11):1218.(第一作者)

19.Lv Z, Qiu L*, Wang W, Liu Z, Liu Q, Wang L, Song L*. RGD-Labeled Hemocytes With High Migration Activity Display a Potential Immunomodulatory Role in the Pacific Oyster Crassostrea gigas. Frontiers in Immunology, 2022, 13:914899. (第一作者)

20.Lv Z, Qiu L*, Wang W, Liu Z, Liu Q, Wang L, Song L*. The Members of the Highly Diverse Crassostrea gigas Integrin Family Cooperate for the Generation of Various Immune Responses. Frontiers in Immunology, 2020, 11:1420.(第一作者)

21.Lv Z, Qiu L, Jia Z, Wang W, Liu Z, Wang L, Song L*. The activated β-integrin (CgβV) enhances RGD-binding and phagocytic capabilities of hemocytes in Crassostrea gigas. Fish & Shellfish Immunology, 2019, 87:638-649.(第一作者)

22.Lv Z, Wang L, Jia Z, Sun J, Wang W, Liu Z, Qiu L, Wang M, Song L*. Hemolymph C1qDC Promotes Oyster Phagocytosis by Interacting with Membrane receptor β-Integrin. Developmental and Comparative Immunology, 2019, 98:42-53.(第一作者)

23.Lv Z, Song X, Xu J, Jia Z, Yang B, Jia Y, Qiu L, Wang L, Song L*. The modulation of Smac/DIABLO on mitochondrial apoptosis induced by LPS in Crassostrea gigas. Fish & Shellfish Immunology, 2019, 84:587-598.(第一作者)

24.Lv Z, Qiu L, Liu Z, Wang W, Chen H, Jia Y, Jia Z, Jiang S, Wang L, Song L*. Molecular characterization of a phagocytes-highly expressed cathepsin L1 from Pacific oyster Crassostrea gigas. Developmental and Comparative Immunology, 2018, 89:152-162.(第一作者)

25.Lv Z, Qiu L, Wang W, Liu Z, Xue Z, Yu Z, Song X, Chen H, Wang L*, Song L. A GTP-dependent Phosphoenolpyruvate Carboxykinase from Crassostrea gigas Involved in Immune Recognition. Developmental and Comparative Immunology, 2017, 77:318-329.(第一作者)

26.Lv Z, Qiu L, Wang M, Jia Z, Wang W, Xin L, Liu Z, Wang L, Song L*. Comparative study of three C1q domain containing proteins from Pacific oyster Crassostrea gigas. Developmental and Comparative Immunology, 2018, 78:42-51.(第一作者)

专利：

1.草鱼白介素10启动子区插入或缺失变异的鉴定分析方法，国家发明专利，2023，第一发明人

2.一种适中免疫水平草鱼亲本的选择方法，国家发明专利，2025，第三

3.一种RGD肽在制备抗水生动物病毒、病毒病药物的用途，国家发明专利，2025，第六

以上信息统计截至2026年1月